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  Bulking Steroids:

  Anabol 5mg British Dispensary
Anabol 50mg - British Dragon
Anabol 50mg, C&K, China
Anabol 5mg - C&K
Anadrol 50 / oxymetholone
Anapolon 50 mg
Anavar
Andriol / Testosterone Undecanoate
ANDRIOL TESTOCAPS 40mg
Androlic 50mg British Dragon
Androlic 50mg British Dispensary
Androlic 50mg, C&K, China
Averbol 25
BONALONE (Oxymetholone)
Clomid 50mg, Global Napi
Cypioject 10 ml vial (200 mg/ml) Testosterone cypionate
Cypionax (Testosterone cypionate)
Danabol, 10mg, 500tabs, DS
Deca Durabolin (Norma)
Deca Durabolin (Organon)
Deca-durabolin 100mg
Deca-durabolin 50mg
Decabol 250 British Dragon
Decadubol-100
Decaject 200
Dubol-100
Dubol-50
Durabol British Dragon
Durabol 200
Durabolin 25
Halotestex British Dragon
Halotestin 5mg
Mastabol 100 British Dragon
Mastabol Depot 200 BD
Metanabol 5mg Poland, Jelfa
Methanabol 10mg 100tabs British Dragon
Methanabol 10mg 500tabs BD
Methanabol 50mg 100tabs BD
Methandriol Dipropionate 75
Methandrostenoloni - 5mg
Nandrolone decanoate
Nandrolone Phenylpropionate
Naposim 5mg
Omnadren
Oxanabol 10mg 50tabs
Oxanabol, 5mg, C&K
Oxydrol 50Mg, 100tabs BritishDragon
Primoteston Depot 1ml amp
Restandol
SustaJect 250 (Ec labs - Eurochem)
Sustanon 250 Pakistan
Sustanon 250mg/1ml Nile
Testabol Cypionate
Testabol Depot, British Dragon
Testabol Enanthate British Dragon
Testabol Propionate 100, 10ml
Testen-250
TESTENON
Testex Elmu Prolongatum 250mg/2ml
TestoJect / 4x testosterone blend
Testosteron Depo 1ml/amp
Testosterone cypionate 200mg
Testosterone Enanthate 250
Testosterone Enanthate 250 Norma
Testosterone Propionate 50mg/ml, Farmak
Testosterone suspension / Aquaviron
Testoviron Depot / Schering
TESTOVIS / testosterone-propionate
Trenabol 75 / British Dragon
Tri-Trenabol 150 BD
Turanabol 10mg

  Cutting Steroids:

  Anadiol Depot, Ilium
Boldabol / British Dragon
Bonavar / Oxandrolone
Cetabon (anabolic formula)
Danabolan
Equipoise 50mL / 50mL - 50mg/1ml
Fluoxymesterone 10mg
Stanabolic 50mg/ml Ilium
Lasix (furosemide)
Orabolin / etylestrenol, 2 mg/tab
PARATABS - Parabolan (trenbolone acetate), 60 tabs (25 mg/tab)
Primobol 100 British Dragon
Primobol tabs, British Dragon
Primobolan Depot
Primoject 10ml
Stanabol 10mg
Stanabol 50injectable (Stanozolol)
Stanabol 50mg British Dragon
Stanabol 50mg C&K
Stanabol 5mg, C&K
Stanoject / Stanozolol
STANOL (stanozolol) 5 mg 200tab
Stanol 50mg/1ml
Stanol 50mg/1ml
STANOZOLOL 1ml x 50mg/ml, LA
Stanozolol 10mg 100Tabs / LA, Italy
STANOZOLOL 50mg/ml ( ILIUM )
Testolic 2ml testosteron propianate
TESTOPIN-100 2 ml vial
Trenabol depot 100mg/1ml
Trenbolone Acetate tabs, BD
Virormone 2ml (Testosterone Propionate) 100mg/1ml
Voltaren 75

  Man's Health:

  Caverject 10mcg, Syringes
Caverject 20mcg
Caverject 20mcg
Propecia 1mg (Finasteride) 28 tabs
Viagra

  Human Hormones:

  Choriomon
Choriomon 15000IU
Igtropin IGF1 LR3 100mcg
Jintropin 10IU(100IU/box)
Jintropin 10IU(200IU/kit)
Jintropin 4IU(40IU/box)
Jintropin 4IU(80IU/box)
Pregnyl 5000 IU Organon
Pregnyl 3 X 5000 IU (HCG)

  Anti Estrogens:

  Anastrozole, - British Dragon
Arimidex / Anastrozole
Aromasin 20 mg / British Dragon
Aromasin 25 mg / Pfizer
Aromasin 25 mg
Clenbuterol / Hubei Huangshi
Clomid 50mg C&K
Clomid 50mg, Aventis
Clomid 50mg, Brunno Farmaceutici
Clomifen 25 mg
Clomiphene 50mg
Clomiphene citrate 50mg
Mesterolone BD (Proviron)
Nolvadex 10mg
Nolvadex, 20mg, AstraZeneca
Nolvadex, 40mg, AstraZeneca
Nolvadex, 50mg, C&K China
Omifin 50 mg 30 tabs
Proviron 25mg (Mesterolone)
Provironum 25mg Schering
Tamoxifen 20mg British Dragon
Teslac (Testolactone) 50mg / 100 tabs

  Anti Depressants:

  ADDERALL XR 15MG CAPSULES
Dumirox (Fluvoxamine) 50mg
Rivotril (CLONAZEPAM) 0.5 mg
Rivotril (CLONAZEPAM) 2 mg
Rivotril (CLONAZEPAM) 2 mg
Rohypnol (Flunitrazepam) 1mg
Valium (DIAZEPAM) 10mg
Valium (DIAZEPAM) 5mg

  Head Ache:

  Maxalt (Rizatripan) 10 mg
Relpax 40mg
Zomigon (Zolmitriptane) 2.5mg

  Herpes:

  Famvir (Famciclovir) 125 mg
Viranet (Valacyclovir) 500mg
Zovirax (Acyclovir) 15 gr

  Muscle Relaxers:

  Baclofen 25mg
Muscoril Caps 20 x 4 mg
Norgesic (Orphenadrine)

  Pain Releaf:

  Advil (Ibuprofen) 200mg
Celebrex 200mg
Mesulid (Nimesulide) 100mg
Movatec (Meloxicam) 15mg
Naprosyn 500mg
Oruvail (Ketoprofen) 200mg
Vioxx 25mg

  Quit Smoking:

  Zyban (bupropion) 150 mg

  Skin Care:

  Harifin 5 (Finasteride) 5mg

  Weight Loss:

  Cynomel 0,025mg (25mcg) (Cytomel / T3) / Liothyronine Sodium
Cytomel / T4 50 mg
Phentermine (blue/clear) 30mg. 100 Caps
Reducil 28tabs 15mg
TRIACANA 0.35 mcg

  Anxiety:

  Vespar

  Genital Warts:

  Aldara cream 5% (Imiquimod)
Wartek (Podophyllotoxin) cream

Igtropin IGF1 LR3 100mcg*10


Name Manufacturer Volume Price $ Price Quantity
Igtropin IGF1 LR3 / 100mcg per vial / 1000mcg per kitGenSci, China1 kit $450  €410  /

 
Igtropin IGF1 LR3 100mcg*10







Igtropin IGF1 LR3 100mcg*10

Although the mechanisms underlying age associated muscle loss are not entirely understood, researchers attempted to moderate the loss by increasing the regenerative capacity of muscle. This involved the injection of a recombinant adeno-associated virus directing overexpression of insulin-like growth factor I (IGF-I) in differentiated muscle fibers.

They demonstrated that the IGF-I expression promotes an average increase of 15% in muscle mass and a 14% increase in strength in young adult mice (Figure 1), and remarkably, prevents aging-related muscle changes in old adult mice, resulting in a 27% increase in strength as compared with uninjected old muscles (Figure 2). Muscle mass and fiber type distributions were maintained at levels similar to those in young adults. These results suggest that gene transfer of IGF-I into muscle could form the basis of a human gene therapy for preventing the loss of muscle function associated with aging and may be of benefit in diseases where the rate of damage to skeletal muscle is accelerated.

Discussion:

I’m not sure where to begin. This study has the potential to completely change the way we age.

In this experiment, a recombinant adeno-associated virus, directing overexpression of insulin-like growth factor I (IGF-I) in mature muscle fibers, was injected into the muscles of mice. The DNA that was originally in the virus was removed along with markers that stimulate immune response. DNA coding for IGF-1 was then put into the virus along with a promoter gene to ensure high rates of transcription. The results, as you can see by figures 1 & 2, were dramatic.

IGF-1 plays a crucial role in muscle regeneration. IGF-1 stimulates both proliferation and differentiation of stem cells in an autocrine-paracrine manner, although it induces differentiation to a much greater degree. IGF-1, when injected locally, increases satellite cell activity, muscle DNA, muscle protein content, muscle weight and muscle cross sectional area. The importance of IGF-1 lies in the fact that all of its apparent functions act to induce muscle growth with or without overload although it really shines as a growth promoter when combined with physical loading of the muscle.

IGF-1 also acts as an endocrine growth factor having an anabolic effect on distant tissues once released into the blood stream by the liver. IGF-1 possesses the insulin-like property of inhibiting degradation, but in addition can stimulate protein synthesis. The insulin-like effects are probably due to the similarity of the signaling pathways between insulin and IGF-1 following ligand binding at the receptors.

The ability of IGF-I to stimulate protein synthesis resembles the action of GH, which was shown in separate studies on volunteers to stimulate protein synthesis without affecting protein degradation. Although it is often believed that the effects of GH are mediated through IGF-1, this cannot be the case entirely. First, the effects of the two hormones are different, in that GH does not change protein degradation. Second, the effect of GH is observed with little or no change in systemic IGF-1 concentrations. Age related muscle loss has been prevented with GH injections, however it is believed that this is accomplished through IGF-1.

The results of this study are similar to other studies where IGF-1 was injected directly into muscle tissue, resulting in increases in size and strength of experimental animals. Using a virus as a genetic vehicle has an advantage over simply injecting the growth factor. The effects of a single viral treatment last significantly longer (months if not years) because the muscle cell itself is constantly overproducing its own IGF-1 from injected DNA.

The fact that the IGF-1 produced by the muscle of these mice did not reach the blood stream is interesting. Systemic injections of IGF-1 have not been successful in inducing this kind of anabolic effect in humans. In addition, IGF-1 produced by the liver is genetically different than that produced by muscle tissue. It could be that providing additional DNA for the muscle to produce it’s own IGF-1 is the key to achieving anabolic and rejuvenative effects specifically in skeletal muscle.

In this study there was a preferential preservation of type IIb muscle fibers in aging mice. These are the fibers most sensitive to muscle hypertrophy from training and they are also the first fibers to disappear with aging. In the mice receiving the engineered virus, there was also a preservation of the motor neuron, leading to an increase in functional capacity. It is speculated that age related muscle loss is secondary to the loss of neuronal activation of type-II fibers. By preventing the degeneration of typ-II motor units, functional capacity could be maintained into old age. This technique may also serve useful in the prevention of osteoporosis. Further study is necessary to determine wether IGF-1 is having an effect only on muscle fibers or on nervous tissues as well.

Finally, it was also exciting to see muscle growth in the young mice who received the injection (15% increase in muscle mass). This means that the injection provided levels of IGF-1 far and above what the muscle normally has access to and not simply a preservation of normal levels. Remember that this was not combined with exercise. The growth of the injected muscles happened even without an extreme mechanical stimulus. The mice were simply allowed to run around as they usually do. Because of these dramatic results, the authors expressed concern about the use of this technique to enhance performance or cosmetic appearance. Research Update is not my personal soap box so I won’t go off on the gender centered hypocrisy of cosmetic enhancement in our society. All we can hope for is that this technique will be used to treat more important diseases such as muscular dystrophy and thereby become somewhat available for other uses as well.








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